What if there was a new approach to clinical trials that addressed pragmatic clinical questions and was far more cost effective than traditional clinical trials?
And what if these trials could be conducted using ‘real world’ patients, rather than the selective populations often used in conventional clinical trials, thereby providing answers that could be readily applied to everyday clinical settings?
These benefits could be realised through a new methodology known as Registry Trials. Registry trials have been successfully applied in cardiovascular research but have not yet been reported in oncology.
The VCCC is exploring the feasibility and viability of Registry Trials as a key program of its Strategic Research Plan.
Thanks to specialised expertise in this area brought by VCCC partner the Walter and Eliza Hall Institute, we will soon begin testing the applicability of the system using selected cancer clinical registries.
The innovative program design incorporates an objective evaluation of all aspects of the registry trial approach. This has led to the creation of an exciting new academic role and the appointment of Dr Khic-Houy Prang as the VCCC Research Fellow in Evaluation of New Clinical Trials Design in the Melbourne School of Population and Global Health at the University of Melbourne. Khic is a health services and policy early career researcher, with wide research experience and expertise in evaluation. She was awarded her PhD in public health from Monash University in December 2016.
Critical evaluation, identify success factors and inform trial design
Khic will analyse the success and applicability of the methodology to provide an in-depth academic assessment of the challenges and opportunities presented by registries based trials. This will include a critical evaluation of the suitability of registry trials in the oncology setting and identify the factors necessary for such trials to succeed – elements that will set our program apart from others internationally. The analysis will provide objective proof of the methodology in the oncology setting and will help inform and improve trial conception and design, assisting the adoption of similar clinical trials worldwide.
Khic will be supervised by Professor Margaret Kelaher, Head of Evaluation and Implementation Science at the Centre for Health Policy, Melbourne School of Population and Global Health.
Congratulations to Khic on this unique fellowship appointment.
‘I’m very excited about the potential of this program. If Registry Trials prove to be a viable option for oncology research in Victoria, this will have significant implications for the scope and scale of cancer clinical trials, accelerating the implementation of more effective treatments and interventions for patients.’
- Professor Peter Gibbs
Laboratory Head Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute
VCCC Program Champion – Registry Trials
VCCC Research & Education Lead – Gastro-intestinal Cancer
Dr Khic-Houy Prang, VCCC Registry Trials Evaluation Fellow, Melbourne School of Population and Global Health, University of Melbourne
Learn more about Registry Trials.